Comparisons of orthodontic root resorption under heavy and jiggling reciprocating forces during experimental tooth movement in a rat model
Hikida Takuji, Yamaguch Masaru, Shimizu iMami, Kikuta Jun, Yoshino Tomokazu, Kasai Kazutaka,
소속 상세정보
( Hikida Takuji ) - Nihon University School of Dentistry Department of Orthodontics
( Yamaguch Masaru ) - Nihon University School of Dentistry Department of Orthodontics
( Shimizu iMami ) - Nihon University School of Dentistry Department of Orthodontics
( Kikuta Jun ) - Nihon University School of Dentistry Department of Orthodontics
( Yoshino Tomokazu ) - Nihon University School of Dentistry Department of Orthodontics
( Kasai Kazutaka ) - Nihon University School of Dentistry Department of Orthodontics
KMID : 0361920160460040228
Abstract
Objective: Root mobility due to reciprocating movement of the tooth (jiggling) may exacerbate orthodontic root resorption (ORR). “Jiggling” describes mesio-distal or buccolingual movement of the roots of the teeth during orthodontic treatment. In the present study, buccolingual movement is described as “jiggling.” We aimed to investigate the relationship between ORR and jiggling and to test for positive cell expression in odontoclasts in resorbed roots during experimental tooth movement (jiggling) in vivo.
Methods: Male Wistar rats were divided into control, heavy force (HF), optimal force (OF), and jiggling force (JF) groups. The expression levels of cathepsin K, matrix metalloproteinase (MMP)-9 protein, interleukin (IL)-6, cytokine-induced neutrophil chemoattractant 1 (CINC-1; an IL-8-related protein in rodents), receptor activator of nuclear factor κB ligand (RANKL), and osteoprotegerin protein in the dental root were determined using immunohistochemistry.
Results: On day 21, a greater number of root resorption lacunae, which contained multinucleated odontoclasts, were observed in the palatal roots of rats in the JF group than in rats from other groups. Furthermore, there was a significant increase in the numbers of cathepsin K-positive and MMP-9-positive odontoclasts in the JF group on day 21. Immunoreactivities for IL-6, CINC-1, and RANKL were stronger in resorbed roots exposed to jiggling than in the other groups on day 21. Negative reactivity was observed in the controls.
Conclusions: These results suggest that jiggling may induce ORR via inflammatory cytokine production during orthodontic tooth movement, and that jiggling may be a risk factor for ORR.
키워드
Experimental tooth movement; Rreciprocating movement; Root resorption; Orthodontic force
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